Iron-Restricted Erythropoiesis in Anaemic Patients with Giant Cell Arteritis and Polymyalgia Rheumatica
نویسنده
چکیده
The aim of this observational study was to biochemically characterize the anaemia in GCA (giant cell arteritis) and PMR (polymyalgia rheumatica) patients. Values for mean corpuscular volume, mean corpuscular hemoglobin and soluble transferrin receptor were normal, whereas serum iron and total iron binding capacity (TIBC) were subnormal, and mean ferritin was above the upper reference limit. Iron-restricted erythropoiesis (IRE), defined as a bone marrow smear staining positive for iron in combination with transferrin saturation less than 20%, was present in all patients. All patients exhibited clinical and biochemical signs of active inflammation with elevated C-reactive protein and an increased erythrocyte sedimentation rate.
منابع مشابه
Discontinuation of therapies in polymyalgia rheumatica and giant cell arteritis.
Glucocorticoids are highly effective in treating polymyalgia rheumatica and giant cell arteritis, but their use is associated with numerous adverse events. Therefore, it is important to use them for the shortest period of time possible. The published evidence suggests that discontinuation of GC is feasible in a substantial number of patients with polymyalgia rheumatica and giant cell arteritis ...
متن کاملLocalized Mesenteric Vasculitis in a Patient with Polymyalgia Rheumatica
Polymyalgia rheumatica (PMR) is an uncommon disorder characterized by bilateral pain and stiffness in the shoulder and pelvic girdles. Polymyalgia rheumatica and giant cell arteritis (GCA) occur in the same patient population and share a common pathogenesis. Giant cell arteritis predominantly affects the cranial arteries and rarely involves the gastrointestinal tract. Moreover, giant cell arter...
متن کاملPulmonary artery obstruction due to giant cell arteritis.
Giant cell arteritis is often referred to in the context of polymyalgia rheumatica with temporal artery involvement. There are, however, more malignant forms of presentation of this necrotizing arteritis involving either the great vessels of the aorta or, occasionally, the pulmonary arteries. Our case relates to giant cell arteritis presenting as pulmonary artery obstruction in a patient withou...
متن کاملTeaching NeuroImages: Polymyalgia rheumatica and giant cell arteritis.
A 62-year-old woman presented with 4 months of neck, shoulder, and hip pain, morning stiffness, and elevated inflammatory markers compatible with polymyalgia rheumatica (PMR). Cervical spine imaging demonstrated ill-defined enhancement in posterior neck soft tissues (figure 1), consistent with interspinous bursitis. She reported right-sided headache. Brain magnetic resonance angiography demonst...
متن کاملGiant cell arteritis and polymyalgia rheumatica.
The close relationship between giant cell arteritis and polymyalgia rheumatica has not been clearly explained. These disorders affect the same patient population and often coexist in the same person. Monitoring of the erythrocyte sedimentation rate is a useful tool in both diagnosis and treatment. Management with varying doses of prednisone has proved effective in resolving symptoms.
متن کامل